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MSDS for Adeno-associated viral vectors

AAV are members of the family Parvoviridae. They are nonenveloped viruses with a singlestranded linear DNA genome. AAV can only replicate in the presence of a helper virus (e.g., adenovirus, herpes simplex virus, cytomegalovirus, vaccinia virus).

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  • PATHOGENICITY

    There are no known health hazards associated with AAV and they are not known to cause disease in humans.

  • MODE OF TRANSMISSION

    AAV are transmitted by inhalation of aerosolized droplets, by contact with mucosa, by parenteral injection and by ingestion.

  • LABORATORY CONTAINMENT REQUIREMENTS

    • Recombinant AAV vector : containment level 1.
    • Recombinant AAV vector in the presence of a helper virus : containment level 2.

  • ANIMAL RESEARCH FACILITY CONTAINMENT REQUIREMENTS

    • Housing of animals infected with recombinant AAV vector : containment level 1.
    • Housing of animals infected with recombinant AAV vector in the presence of a helper virus and/or the gene of interest coding for a toxin or an oncogene : containment level 2.

  • DISINFECTANTS

    • 0.5% sodium hypochlorite (1/10 dilution of bleach), 2% glutaraldehyde and 0.25% sodium dodecyl sulfate.
    • Alcohols (ethyl and isopropyl) not effective.

  • PHYSICAL INACTIVATION

    Autoclave : 121°C, 30 minutes, 15 psi.

  • ADDITIONAL INFORMATION

    • « Laboratory Biosafety Guidelines », Public Health Agency of Canada.
    • « Containment Standards for Veterinary Facilities », Canadian Food Inspection Agency.
    • « Guidelines for Research Involving Recombinant DNA Molecules », National Institutes of
      Health.
    • « Guidance on Biosafety Considerations for Research with Lentiviral Vectors », National Institutes of Health.
    • Web site of the Comité universitaire de gestion des risques biologiques.

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